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An ocular prosthesis creates an illusion of a normal eye and its surrounding tissues, and maintains the volume of its socket [1]. The accurate duplication of color, contour, size and orientation, similar to that of a natural eye, is important in order to obtain realism and symmetry [2]. The methods of fabricating ocular prostheses have progressed over the years to provide superior cosmetic replacement of the enucleated or eviscerated eye [1]. The procedure that constitutes the removal of the contents of the globe, leaving the sclera, extraocular muscles and optic nerve intact, is called evisceration.

The defect is usually corrected using a sclera cover shell prosthesis [3].

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If you’re familiar with the name Gilles Peterson , you probably know that dude is one of the great diggers of our time, pulling out some of the most amazing obscuro tracks, founding influential labels, and just plain being an amazing DJ. Check out the below video on Gilles Peterson’s introduction to the man from outer space and order your copy of his comp , an excellent primer for Sun Ra. A new analysis of Hubble data has revealed the best candidate yet for a type of black hole that nobody has seen yet, and it gave itself away by tearing a star apart.

The “dark” black hole is so close to Earth that you can see the system it’s in with the naked eye, and hints that there may be many more hidden black holes in the universe. Or: a comprehensive list of all the worst men you’ve ever slept with. The former teen sensation told VICE about his first major album placement and why he keeps getting roasted on Instagram Live. From Anz to Yaya Bey, these under-the-radar releases deserve more love than they got.

A fan’s public revelation about Rage Against the Machine’s activist stance reveals the puzzling ways people tune out the obvious. Emerging out of an already thriving scene in Limerick, this collective of rappers and producers are re-imagining American rap styles through a working-class Irish lens. Read Watch. The legendary DJ and music genius talk about the creation of his new comp, culled from more than one hundred LPs and songs.

Becky Ferreira.

He’s Gonna Make It All OK: An Oral History Of Elliott Smith’s Darkly Beautiful Self-Titled Album

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The occurrence of tolerance or host unresponsiveness in animals and humans administered multiple doses of microbe or microbial products has long been recognized by scientists and physicians with published reports appearing in professional journals dating back to the 19 th century. Following the identification and purification of lipopolysaccharide LPS in the 20 th century, it was determined that the microbial product, LPS itself, can be highly tolerogenic.

From these observations, it has been postulated that tolerance serves to protect the host from the detrimental consequences of the robust and extensive inflammatory responses that follow exposure to LPS. Tolerance cannot, however, be characterized as a global downregulation of responsiveness as some LPS-responsive characteristics remain unchanged or in some cases can actually be upregulated in experimental models of tolerance.

In studies carried out by numerous investigators over the years to clarify the concept of tolerance, a variety of terms have been used to designate the observed alteration in immune responses that occur upon repeated administration of LPS. All are arguably accurate to some extent, although many of these should not be used interchangeably, as some of these terms refer to tolerance that can be established only under specific conditions.

Numerous studies have been dedicated to the elucidation of LPS structures from various microbes in order to account at the molecular level for LPS tolerance. From these studies, it has been established that the lipid A moiety of LPS is responsible for almost all of the described activities of LPS. In this regard, both early and late tolerance have been described.

Early tolerance is usually observed within hours of LPS administration and may last up to a week or more. During early tolerance, suppression of cytokine production, fever, and endotoxin lethality occur independently of antibody production. In contrast to early tolerance, late tolerance is induced many days after LPS treatment when early tolerance has generally ceased or markedly waned.

Late tolerance is characterized by the production of antibodies directed against LPS, which confers the specificity and lack of cross-tolerance observed in this phase.

How to Crack the Code of Sun Ra, According to Legendary DJ Gilles Peterson

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The longer Elliott Smith has been gone, the closer his listeners have felt to him. Since his untimely death at 34 years old in , Smith’s closest friends and family have seen his masterfully empathic songwriting give that intimate companionship to countless fans. The 25th anniversary reissue of his self-titled album, due Aug.

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